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Clinical Intervention Modelling, Planning
and Proof for Ablation Cancer TreatmentPhysiological Radio-Frequency Ablation (RFA) model for liver cancer treatmentBringing the existing RFA model into clinical studyRFA planning and support tool offering a validated software environmentco-funded by the European Union’s Seventh Framework Programme -
Scientific and technological objectivesPatient specific RFA prediction adapted to the clinical environmentReal-time needle position update and RFA predictionDecision supporting and error aware real-time visualization during interventionsClinical RFA intervention planning and supportClinical validation of the RFA model and its integration into the clinical workflow -
Clinical objectivesDefinition of technical pre-requisites of the clinical studySatisfaction of ethical and regulatory requirements of the clinical studyFinalisation of the clinical study protocol and Case Report FormTraining of the medical personnel
ClinicIMPPACT
Clinical Intervention Modelling, Planning and Proof for Ablation Cancer Treatment
Physiological model for Radio-Frequency Ablation (RFA) therapy of liver cancer
Interactive patient-specific simulation, planning, validation of RFA therapy in the liver
Interventional Radiologists (IR) can observe the extent of necrotic region and update the heating protocol during the RFA procedure
ClinicIMPPACT is a European ICT-Project funded by the European Union’s Seventh Framework Programme for research, technological development and demonstration under grant agreement No: 610886
Objectives
The main objective of ClinicIMPPACT is to bring the existing Radio-Frequency Ablation (RFA) model for liver cancer therapy into clinical practice.
The project pursues the following objectives:
Clinical Study
To prove and refine the RFA model in a small clinical study
Training procedure
To establish a corresponding training procedure for IR's
Development of the real-time patient-specific RFA planning and support system
To integrate the model into a real-time patient-specific RFA planning and support system for Interventional Radiologists (IR) under special consideration of their clinical workflow needs
Evaluation of the RFA model in practical use
To evaluate the clinical practicality and benefit of the model's use in the routine workflow in a user survey
About ClinicIMPPACT
Problem and Context
For many of the Radio-Frequency Ablations (RFA) performed in the liver, there is still a significant mismatch between expected and truly induced lesion size. This can lead to over-treatment with severe injuries (up to 9% major complications), or under-treatment with tumour recurrence (up to 40%).
The proposed RFA planning and support tool is therefore unique as it offers a validated software environment, where IRs can interact during the RFA treatment with the virtual tumour ablation through the extensive use of simulation and visualisation technology.
RFA Guardian
Integrated accurate tool for computing a RFA-induced necrosis region in liver tissue.
Sophisticated multi-disciplinary development, comprising image processing, perfusion measurement, real-time simulation, and visualization, ensures accurate patient-specific real-time simulation of the RFA therapy.
Clinical Study
The clinical study is at the core of the project. The patient data acquired in the study is used to validate the simulated necrosis region and to optimize the model parameters to achieve a better simulation accuracy. The RFA model is adapted to real-time requirements of the clinical environment and integrated into the clinical workflow.
The ClinicIMPPACT Project Consortium unites 8 partners from research and industry.
Coordinated by Fraunhofer Society the consortium builds upon expertise of 3 technical university partners complemented by 4 university clinics.
